Genome Analysis across Populations (GAP)
Details of Research
Contact: Joanne Stempak, Project Manager
416-586-4800 ext 8399
joanne.stempak@sinaihealth.ca
Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD across all populations
Eligibility:
IBD Subjects
Available medical records to confirm IBD diagnosis (Crohn’s disease, Ulcerative colitis, IBD undetermined (IBD-U)) *medical release required for non-MSH patients
Any age
Healthy Controls
No personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
Any Age
Participation involves:
- One-time blood (preferred) or saliva sample
- Collection of clinical data
Background:
Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among non-Europeans may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD.