Eligibility
Inclusion criteria:
- Patients with UC or IBD-U refractory to medical therapy or with dysplasia
- Patients undergoing a 1-, 2-stage, 3-stage approach
- Between 18 years old and 60 years old.
- Speak English and/or primary language of recruiting center.
- Provide informed consent
Exclusion criteria:
- Patients with familial adenomatous polyposis (FAP);
- Patients with contraindications for laparoscopic surgery including previous laparotomy, toxic megacolon and chronic obstructive pulmonary disease (COPD) Gold III or higher;
- Patients still taking steroids at the time of proctectomy and IPAA construction. A wash-out period of 8 weeks will be considered for all treatments before performing the pouch construction.
- Patients with confirmed or suspected rectal cancer;
- Patients with primary sclerosing cholangitis (PSC)
- Patients needing a hand-sewn anastomosis;
- Redo-pouch surgery
- Pregnancy and lactation (tested by a urinary pregnancy test)
- Patients undergoing an urgent or emergent proctocolectomy. Those patients are still eligible if they undergo a subtotal colectomy first and a completion proctectomy in a second stage.