IBD Research at the Zane Cohen Centre

Information on research and clinical trials in Inflammatory Bowel Disease

Current Studies

Crohn's Disease & Ulcerative Colitis

• Diverse Ancestry Study in IBD
  To better define the genetic and environmental factors that contribute to IBD in diverse ancestries (Black, Hispanic/LatinX)

• Characterization of the Intestinal Microbiome in Patients with and without PSC
  The objective is to assess the composition of the microbiome in patients with and without PSC, IBD patients without PSC (Ulcerative colitis and colonic Crohn’s disease) and healthy controls.

• Genetic Analysis of Infliximab-treated Inflammatory Bowel Disease Patients
  Objective is to identify differentially expressed genes between responders and non-responders to Infliximab therapy and to examine if significant gene expression differences exist between Infliximab-treated Ulcerative colitis and Crohn’s Disease patients.

• The Identification of Genes for Inflammatory Bowel Disease
  Objective is to identify new genes or biomarkers that may be responsible for causing Inflammatory Bowel Disease (IBD) and understand the role of previously identified genes in IBD.

• Dietary Information (Food Diaries), Tissue (Biopsy) collections and Stool collections for IBD studies
  Objective is to understand how diet and other biomarkers may affect the gut microbiome in IBD.

• The CCFC Michael J. Howorth GEM Project
  To Identify why some individuals develop Crohn's Disease and others do not. This is accomplished by following healthy individuals considered to be at high risk for developing Crohn's disease over several years and measuring several factors before and after a diagnosis of Crohn's disease is made.

• The ENABLE Study (Equitability of Insurance Access to Biologics and its Impact on Effectiveness)
  Objective is to formally assess the time interval from application for coverage of anti-TNF therapy (including Remicade and Humira) to first dose for privately vs. publicly insured patients with Inflammatory Bowel Disease (IBD) and to study whether potential delays in access to this therapy will have an effect on health outcomes such as hospitalization or surgery.

• Complementary and Alternative Medicine (CAM): Prevalence and Longitudinal Impact on Adherence to Conventional Therapy in Inflammatory Bowel Disease
  Objective is to gain insight into the use complementary and alternative medicine (CAM) among patients with Inflammatory Bowel Disease (IBD), the different types of CAM, and perceived benefits of CAM that will help us better understand patients and potentially lead to better care.

• The SAFE Study (Survey on Awareness of Extraintestinal Inflammatory Bowel Disease)
  Objective is to assess Inflammatory Bowel Disease patients' awareness of extra intestinal manifestations associated with Inflammatory Bowel Disease and inquire about where patients obtain their information on IBD.

• Barriers and Facilitators to medication compliance in IBD patients
  The main aim of this study is to explore the perspectives of individuals with IBD in Toronto, Canada on barriers and facilitators to the compliance of medication.

Ulcerative colitis

• The UC Relapse Study: Gene expression profiles and microbial predictors of relapse in Ulcerative Colitis
  To evaluate the genetic, microbial and other factors associated with remission and relapse in patients with Ulcerative Colitis (UC).

• Evolution of the Microbiome in a Pelvic Pouch Model: A Prospective Study to Understand Mechanisms of Ileal Inflammation
  To examine the evolution of the microbiome in the pouch, and its association with pouch inflammation.

• Diet intervention as a prebiotic treatment for active ulcerative colitis
  Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of an investigational medication for treating Ulcerative colitis.

Crohn's Disease

• Mechanisms of Intestinal Inflammation Following Ileal Resection for Crohn's Disease
  Objective is to evaluate microbial and gene expression factors which are associated with the recurrence of small bowel inflammation following surgery for Crohn’s Disease. This will have practical implications for evaluating which patients are more likely to rapidly recur as well as provide insight into the pathogenesis of Crohn’s Disease.

• Hepatobiliary Bowel Study

• Clinical Trial for a new oral medication in Crohn's Disease
  Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of an investigational medication for treating Crohn’s Disease

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